The provincial police commandment in a statement said unmanned aerial vehicles belonging to the US forces targeted the loyalists of the terror group in Haska Mina district.
The statement further added that the militants were targeted in the vicinity of Awghaz area of the district on Sunday, leaving two of them dead.
The anti-government armed militant groups including the ISIS militants have not commented regarding the report so far.
Nangarhar is among the relatively calm provinces however the Taliban and ISIS militants have increased their insurgency activities in some its remote parts during the recent years.
At least fourteen militants affiliated with the terror group were killed in an airstrike conducted in this province on Saturday.
The provincial government media office issued a statement on Saturday afternoon and said the target of the airstrike apparently was senior ISIS leaders who were killed in the airstrike
The militants were targeted in the vicinity of Margha area of Mamand Dara of Achin district, the statement said, adding that the two ISIS leaders killed in the raid have been identified as Asadullah Orakzai and Shakirullah Kunari.