Pakistani intelligence sources confirmed that the airstrike was carried out early Wednesday in Miramshah Tehsil of North Waziristan.
The sources further added that a compound and a vehicle in Dargah Mandi village were targeted by at least six missiles fired by a drone.
Sources also added that the identities of those killed in the strikes have not yet been ascertained.
This was the third airstrike carried out by US drones in a month time in North Waziristan where a comprehensive military operation launched by the Pakistani army against foreign and local terrorists is also under way.
The Pakistani army launched its long-awaited major operation ‘Zarb-i-Azb’ in the tribal region a week after an attack on the airport in Karachi, deploying troops, tanks and jets to the area in the crackdown on the Taliban and other militants.
At least 16 suspected militants were killed following two successive drone strikes in North Waziristan earlier.