The Pakistani intelligence sources have said the airstrike was carried out in Shawal area of South Waziristan.
The sources further added that a senior Uzbek commander were among five killed following the airstrike and three others were also injured.
This comes as at least suspected militants were killed following a US drone strike in South Waziristan late last month.
The airstrike, carried out in Wana area of South Waziristan killed two Arab and two Pakistani militants.
The drone strikes in Pakistan resumed after almost six months gap in June when two successive drone strikes on June 11 reportedly killed around 16 people in Miranshah.
U.S. drone strikes are widely unpopular in Pakistan, where many consider them a violation of the country’s sovereignty that also killed civilians.
But American officials believe they are a vital weapon in the war against militants.