The provincial security commandment in a statement said the airstrike was carried out in the vicinity off Nazian district.
The statement further added that the US forces carried out an airstrike on a hideout of the ISIS Khurasan group in Do Khole area of the district, using unmanned aerial vehicles.
According to the provincial security commandment, the airstrike left at least two ISIS Khurasan militants dead.
The airstrike did not inflict casualties on the local residents and the security personnel involved in counter-terrorism operations, the statement added.
Nangarhar has been among the relatively calm provinces since the fall of the Taliban regime in 2001 but the anti-government armed militants have been attempting to expand their foothold in this province during the recent years.
However, the Afghan armed forces are busy conducting counter-terrorism operations to suppress the militant groups.