The attack took place in the Mir Ali area, some 35 kilometres (21 miles) east of Miranshah, the main town of North Waziristan tribal district, a stronghold of Taliban and Al-Qaeda-linked militants along the Afghan border.
An intelligence official said, the drone strike took place at around 11:30 p.m. The two victims, whom the authorities believed to be militants, were riding a motorcycle when they were targeted by the drone strike.
The official further added, the attack damaged nearby houses, but no other casualties were immediately reported.
Attacks by unmanned American aircraft are deeply unpopular in Pakistan, but Washington views them as a vital tool in the fight against Taliban and Al-Qaeda militants in the lawless tribal areas along the border with Afghanistan.
The strike was the second one in July. The previous strike occurred July 2, killing at least 17 people, also in North Waziristan.