The Ministry of Defense (MoD) said the airstrike was carried out by the Afghan Air Force in Hesarak district.
MoD further added that Mawlavi Mumtaz Mia Khel the group’s shadow governor for Kabul was killed along with his 15 fighters in the raid.
Another senior Taliban commander identified as Mullah Tor was also among those killed and a vehicle belonging to the group was confiscated by the Afghan forces.
The anti-government armed militant groups including the Taliban militants have not commented regarding the report so far.
Nangarhar is among the relatively volatile provinces in eastern Afghanistan where anti-government armed militants are actively operating in a number of its districts and often carry out insurgency activities.
The airstrike in Hesarak comes as the Taliban militants launched a coordinated attack on several security out posts in this district few days earlier.
The officials had warned that the district is the brink of collapse if additional forces are not deployed to repulse the Taliban attack.