According to the local security officials, the operation was launched late on Friday night in parts of Kunduz province, near the main highway connecting Kunduz and northeastern Takhar province.
Provincial police chief Mohammad Qasim Jangalbagh said at least 20 Taliban insurgents were killed and 6 others were wounded during the operation.
The clearance operations are currently underway in certain villages and parts of Kunduz which threaten the main highway, the officials added.
The highway going through Kunduz is considered as one of the main highways in northern Afghanistan which connects northeastern Takhar with Badakhshan and Kunduz provinces.
The anti-government armed militants are usually threatening the highway by conducting insurgency activities, mainly in Kunduz province where the Taliban insurgents are having a widespread presence.
The Taliban militants launched a major offensive during the recent weeks in a bid to capture key parts of Kunduz province, including the strategic Kunduz city which was seized by the group last year.