According to the local officials, the Taliban leader Mawlavi Ahmad Masroor, was killed along with fifteen others in Greshk district.
The officials further added that the airstrike was carried out late on Sunday evening and as a result two other senior Taliban leaders were also killed.
The provincial government media office in a statement confirmed that the airstrike was carried out in Shoraki area.
The statement further added that the two other senior Taliban leaders killed in the airstrike has been identified as Mullah Sediqullah and Mawlavi Sajad.
The airstrike was carried out as the Taliban insurgents were looking to shift six suicide bombers to Nahr-e-Saraj district, the statement added.
The anti-government armed militant groups including the Taliban militants have not commented regarding the report so far.
Helmand is among the volatile provinces in southern Afghanistan where the Taliban insurgents are actively operating in its various districts and frequently carry out insurgency activities.