According to a statement by MoD, the airstrikes were conducted in three different districts of Helmand, including the provincial capital Lashkargah city.
The statement further added that twelve insurgents were killed in total including three of their local commanders.
The Taliban commanders killed during the airstrikes have been identified as Mullah Khaliqdad, Mullah Musafir, and Khayal Mohammad, MoD added.
According to the Ministry of Defense, at least thirteen insurgents were also wounded during the same airstrikes.
The airstrikes targeted the hideouts of the insurgents that led to the casualties to the Taliban insurgents, MoD said, adding that four hideouts of the group were destroyed in total.
The anti-government armed militant groups have not commented regarding the report so far.
Helmand remains one of the most volatile provinces in southern Afghanistan since the fall of the Taliban regime in 2001 where terrorist related incidents are frequently reported from its various districts.