The Ministry of Defense (MoD) said the airstrike was carried out in Marjah district by the Afghan Air Force.
According to a statement by MoD, a weapons and explosives cache belonging to the Taliban group was also destroyed and along with a command control center of the group in Marjah.
The Taliban militants group has not commented regarding the report so far.
Helmand is among the volatile provinces in southern Afghanistan where anti-government armed militant groups are actively operating and frequently carry out insurgency activities.
The Taliban militants kidnapped scores of passengers from a highway in Greshk district of Helmand province on Tuesday on charges of working for the government security institutions.
In the meantime, at least 9 hostages were released and a command and control center of the Taliban group was destroyed during an operation in Nahr-e-Saraj district last week.