According to local government officials, the incident took place in Ghani Khel district on Tuesday morning.
Provincial governor spokesman, Ahmad Zia Abdulzai, said the suicide bomber detonated his explosives after the vehicles of the police forces arrived to inspect regarding a suicide attack plot.
Taliban group spokesman, Zabiullah Mujahid, claimed responsibility behind the attack and said at least 6 policemen were killed and 10 others were injured following the attack.
Nangarhar is among the relatively volatile provinces in eastern Afghanistan where Taliban militants are active in a number of its districts and frequently carry out insurgency activities.
At least eight people including two civilians and 6 militants were killed after a group of militants attacked the intelligence office in Nangarhar province last week.