According to the local security officials, the airstrike was carried out by the coalition forces in Achin district, using an unmanned aerial vehicle.
Provincial police spokesman Hazrat Hussain Mashriqwal said the loyalists of the terror group were targeted in Mamand Dara and Pekha areas of Achin late on Sunday afternoon.
He said two prominent commanders of the terror group were among those killed which included a number of the foreign militants as well.
The drone strike by coalition forces comes amid ongoing military operation by the Afghan national security forces in Achin and Nazian districts, being conducted under the name of Shaheen-18.
The US Forces in Afghanistan have increased air campaign against the terror group in this province, carrying at least 20 airstrikes between late January and early February.
According to reports emerging earlier this month, the US forces in Afghanistan carried out at least 20 airstrikes targeting the loyalists of the terror group in a period of three months from late January to early February.
The coalition officials estimate around 1,000 to 3,000 Islamic State fighters are stationed in in eastern Afghanistan and are trying to establish a base of operations in the rugged mountains of Nangahar Province.