The provincial government media office in a statement said the incident took place at around 1:15 local time in Sultan Ghazi Baba Township after explosives planted a motorcycle went off.
The statement further added that a religious cleric identified as Mawlavi Mohamamd Younus Shama Khel was among those killed and thirteen civilians were wounded.
According to the provincial government, the incident took place shortly after the religious cleric left the mosque and was on his way towards his residence.
The health condition of two sons of Mawlavi Younus and another civilian has been reported as critical, the statement said, adding that the wounded individuals have been shifted to Nangarhar provincial hospital for the treatment.
Provincial governor Mohammad Asif Nang condemned the attack and instructed the relevant authorities to launch a thorough investigation into the incident.