According to local government officials, the airstrike was carried out in Gayan district early on Saturday morning.
A local security official speaking on the condition of anonymity confirmed that 18 Taliban insurgents including foreign fighters were killed following the air raid.
The Taliban militants group has not commented regarding the incident so far.
Paktika is among the volatile provinces in eastern Afghanistan where anti-government armed militants are actively operating in its various districts and frequently carry out insurgency activities.
This comes as a suicide bomber was shot dead by Afghan national securty forces in Orgun district last week.
At least 57 people were killed and several others were injured after a suicide bomber targeted the spectators of a volleyball match in Yahya Khel district a month ago.