The 203rd Thunder Corps of the Afghan Military in the Southeast said the latest airstrike was carried out in the vicinity of Syedabad district.
A statement by 203rd Thunder Corps stated that the militants were targeted in Zargul area of the district, leaving at least 30 militants dead.
The statement further added that 22 militants also sustained injuries during the same airstrike.
The anti-government armed militant groups including Taliban militants have not commented regarding the report so far.
Paktia has been among the relatively calm provinces in southeaster parts of the country since the fall of the Taliban regime in 2001.
However, the security situation of the province has deteriorated during the recent years amid ongoing efforts by the anti-government armed militant groups to expand their insurgency in key provinces in southeastern parts of the country.