The provincial police commandment in a statement said the airstrike was carried out by the US forces with unmanned aerial vehicles on Sunday.
The statement further added that two ISIS members were killed in the airstrike carried out in Achin district.
According to the provincial government, a key member of the terror group identified as Qari Zahid was among those killed.
This comes as operations are underway for the elimination of the ISIS and insurgent of the other groups in Nangarhar province.
At least four people including two Pakistanis have been arrested on charges of supplying weapons and ammunition to the anti-government armed militant groups in this province on Saturday.
The provincial government in a statement said Sunday that the men were arrested during an operation from Momand Dara district and as the suspects were attempting to smuggle eight rounds of rocket launcher missiles placed in a vehicle.
Two of the detained insurgents have confessed that they belong to Khyber Pakhtunkhwa of Pakistan while the two others are residents of Momand Dara district, the statement said.
The provincial government also added that the detained individuals have also confessed that they were attempting to transport the weapons to the insurgent groups.