The provincial government media office in Nangarhar said the two militants were apparently operating as snipers and were killed in Haska Mina district.
The statement further added that the airstrike was carried out in the vicinity of Gagar area late on Wednesday night.
According to the governor’s office, two sniper rifles belonging to the militants were also destroyed in the airstrike.
The ISIS terrorist group loyalists have not commented regarding the latest US drone strike in Nangarhar province so far.
This comes as counter-terrorism operations are underway against the ISIS and other militants in different districts of Nangarhar province.
The US forces based in Afghanistan also carried out airstrikes almost on regular basis as the Afghan forces are engaged in counter-terrorism clearance operations.