The provincial government media office in a statement said at least two foreign ISIS militants were killed in an airstrike conducted in Nazian district late on Friday night.
The statement further added that the airstrike by the unmanned aerial vehicles was carried out in Lal Mandawi area, leaving three Pakistani nationals dead, including the military commission of ISIS group.
According to the Nangarhar government, the slain ISIS leader has been identified as Syd Wali andhe was a resident of Khyber Pakhtunkhwa of Pakistan.
The anti-government armed militant groups including the ISIS terrorists have not commented regarding the report so far.
Nangarhar is among the relatively calm provinces in East of Afghanistan but the security situation of the province has started to deteriorate during the recent years.
At least three Taliban insurgents were killed in a similar airstrike conducted on Thursday evening, the local officials said Friday.
According to the officials, the latest airstrikes were carried out late on Thursday evening in the vicinity of Ghani Khel district that left three Taliban insurgents dead while their weapons, ammunition, and explosives were also destroyed.