The provincial government media office in a statement said the militants were killed during infighting in the restive Achin district.
In the meantime, the provincial government said at least fifteen ISIS militants were killed during the operations in Haska Mina district.
The statement further added that the operations were conducted in the vicinity of Kham Miran area during the operations involving airstrike.
According to the provincial government, the operations were launched shortly after the ISIS militants launched a coordinated attack on the security posts.
The anti-government armed militants and terrorist groups including ISIS loyalists have not commented regarding the report so far.
Nangarhar has been among the relatively calm provinces until recent years as fewer terrorist related incidents were reported from the province since the fall of the Taliban regime.
However, the Taliban and ISIS militants along with the other militants have been attempting to expand foothold in this province during the recent years.