The 201st Silab Corps of the Afghan Military in the East said the airstrike was carried out in the vicinity of Nazian district.
The source further added that one militant affiliated with the Islamic State of Iraq and Syria (ISIS) terrorist group was killed in the airstrike.
Nangarhar is among the relatively calm provinces in the East but the anti-government armed militant groups including Taliban and ISIS militants have been attempting to expand their foothold in some remote parts of the province during the recent years.
This comes as counter-terrorism operations and airstrikes are underway in different parts of the country against ISIS and other militant and terrorist groups.
The 201st Silab Corps of the Afghan Military in the East said Saturday that the US forces based in Afghanistan carried out a series of airstrikes on ISIS hideouts in Khogyani district.
The source further added that the militants were targeted in Zawa area of the district by unmanned aerial vehicles and as a result at least six militants were killed.