According to the local officials, the latest drone was carried out on Wednesday in the vicinity of Chapa Dara district.
Provincial governor’s spokesman Faridullah Dehqan said at least two commanders of the terror group were among those killed.
He said the US forces based in Afghanistan carried out airstrike on ISIS hideouts in Chapa Dara district on Wednesday that left six militants dead.
The ISIS terrorist group loyalists have not commented regarding the report so far.
This comes as at least two militants affiliated with the terror group were killed in a similar airstrike conducted in the same district nearly a week ago.
The US forces frequently carry out airstrikes on ISIS targets in the restive porvince of the country as ground operations as well as airstrikes are also being conducted against the group by the Afghan forces.
The local officials in Nangarhar said Wednesday that three ISIS militants hailing from Uzbekistan were killed in a similar airstrike in Haska Mina district.