According to the local security officials, the airstrike was carried out in Kot district targeting the loyalists of the terror group on Monday evening.
The officials further added that the airstrike also destroyed some weapons of the ISIS loyalists but no civilian casualties were reported.
The anti-government armed militant groups have not commented regarding the report so far.
The US forces stepped up airstrikes against the ISIS loyalists earlier this year after they were granted more authorities by President Barack Obama.
The increased raids against ISIS loyalists followed amid concerns that they are attempting to expand foothold in the country besides attempting to consolidate operations with the terror group in Iraq and Syria.
This comes as the loyalists of the terror group launched a major attack police check posts nearly ten days which resulted to heavy clashes.
Local officials said over 200 ISIS loyalists, more than 10 Afghan security personnel and several civilians were killed during the clashes.