The provincial government media office in a statement said at least three ISIS Khurasan militants were killed in drone strikes conducted in Mulki and Awghez areas of Haska Mina district.
The statement further added that the airstrikes were carried out late on Thursday night.
In the meantime, the Afghan forces responded to the attacks by the Taliban militants in Jihadi Lisa, Ghazi and Folad areas of Khogyani district, leaving at least three militants dead.
According to the provincial government, at least five militants also sustained injuries during the clashes.
The anti-government armed militant groups including Taliban militants have not commented regarding the report so far.
Nangarhar has been among the relatively calm provinces since the fall of the Taliban regime in 2001 but the anti-government armed militants have been attempting to expand their foothold in this province during the recent years.
However, the Afghan armed forces are busy conducting counter-terrorism operations to suppress the militant groups.