The provincial government media office in a statement said a militant was killed while he was developing an improvised explosive device in his house in Ghani Khel district.
The statement further added that the IED expert was killed instantly after the explosives went off during the making of the improvised explosive device.
The provincial government also added that the US forces conducted airstrike in Awghaz area of Haska Mina district, leaving at least seven ISIS Khurasan militants dead.
In separate airstrikes conducted in Nazian and Achin districts, at least 5 ISIS Khursan militants were killed, the provincial government added.
The statement also added that the local residents and security personnel have not suffered casualties during the operations.
Nangarhar has been among the relatively calm provinces since the fall of the Taliban regime in 2001 but the anti-government armed militants have been attempting to expand their foothold in this province during the recent years.
However, the Afghan armed forces are busy conducting counter-terrorism operations to suppress the militant groups.