According to local security officials, the incident took place after a suicide bomber detoanted his explosives during Eid prayer.
The official further added that the governor was killed following the blast and 20 others were also injured following the blast.
Provincial governor spokesman, Din Mohammad Darwish confirming the report said the explosion took place after an explosive device which was planted inside the mosque went off.
Mr. Darwish further added that more than 20 others including the Imam of the mosque were injured following the explosion.
Arsala Jamal was previously serving as provincial governor for eastern Khost province of Afghanistan, and he had survived multiple attacks by militant groups.
No group including the Taliban militants has so far claimed responsibility behind the incident.