The blast took place in Qarabagh district targeting a vehicle of the Afghan National Police (ANP) forces.
The district administrative chief Abdul Wasey Sharifi said the incident took place around 11:00 am local time.
Sharifi further added that six policemen lost their lives and two others were wounded following the explosion.
The Ministry of Interior (MoI) confirmed that two six people including four policemen and two civilians lost their lives following the explosion.
No group including the Taliban militants has so far claimed responsibility behind the incident.
Taliban militants and insurgents from the other militant groups frequently use Improvised Explosive Device (IED) as the weapon of their choice to target the security forces. The IEDs are also major contributor to civilian casualties in Afghanistan.