The incident took place in the vicinity of Jaghori-Gilan highway after an Improvised Explosive Device (IED) targeted a civilian vehicle.
Deputy provincial governor Mohammad Ali Ahmadi said four women, three men and a child were among those killed.
Ahmadi further added that the civilians were all travelling inside the vehicle which struck with the roadside bomb.
No group including the Taliban militants has so far claimed responsibility behind the incident.
Taliban militants frequently use improvised explosive device as the weapon of their choice to target the security forces which normally leads to civilian casualties.
Ghazni is among the volatile provinces in southeastern Afghanistan where anti-government armed militants are actively operating in its various districts.