According to local security officials, the airstrike was carried out earlier today in Kamdish district.
A spokesman for the Afghan National Army 201 Silab Corps Haroon Yousufzai confirmed that the militants were targeted in Chenar Khor area on Sunday morning.
The anti-government armed militant groups have not commented regarding the report so far.
Nuristan is among the volatile provinces in eastern Afghanistan where anti-government armed militant groups are actively operating in its various districts and frequently carry out insurgency activities.
Dozens of Taliban militants launched a coordinated attack on an Afghan National Army (ANA) military base in Kamdish district early on Saturday.
According to local security officials, at least 22 militants were killed along with two Afghan army soldiers following the clashes.