The airstrike was carried out by US forces in Obe district of Herat province on Friday.
Obe district chief, Sher Aqa Alokozay, said the Taliban leader Mullah Sharaf who was also known as Mullah Shoaib was killed following the airstrike in Tagab Yari area.
Alokozay further added that Mullah Sharaf was involved in major terrorist activities in Obe district.
He said the death of Mullah Sharaf will have a positive impact over the security situation of Obe district.
Taliban militants group has not commented regarding the report so far.
Herat is among the relatively peaceful provinces in western Afghanistan but the anti-government armed militant groups have increased to their insurgency activities in a number of its districts during the recent years.