The provincial police commandment in a statement said at least fort militants of the terror group including some foreigners were killed in the airstrikes.
The statement further added that the airstrike were carried out in the vicinity of Makrana area in the restive Achin district.
Several hideouts, light and heavy weapons belonging to the insurgents were also destroyed during the airstrikes, the police commandment said.
The anti-government armed militant groups including the ISIS loyalists have not commented regarding the report so far.
Nangarhar is among the relatively calm provinces in eastern Afghanistan but the anti-government armed militant groups have recently increased their insurgency activities in some parts of the province during the recent years.
This comes as an anti-ISIS operation is underway in Nangarhar to eliminate the presence of ISIS affiliates in this province.
The US forces in Afghanistan on Wednesday also confirmed that a US soldier was killed and some Afghan and US troops were wounded during the anti-IS operations in eastern Afghanistan.