The Ministry of Defense (MoD) in a statement said the airstrike was carried out in the vicinity of Achin district.
The source further added that a weapons and munitions depot of the terror group was targeted in the airstrike and as a result at least three militants were killed.
According to the Ministry of Defense, several weapons, munitions, and explosives were also destroyed during the airstrike.
Nangarhar has been among the relatively calm provinces in East of Afghanistan but the anti-government armed militants have been attempting to expand their insurgency in this province during the recent years.
Militants belonging to the Taliban group as well as the ISIS Khurasan are active in some remote districts and parts of the province.
In the meantime, counter-terrorism involving airstrikes, both from the Afghan and US forces are underway to suppress the activities of the anti-government armed militants in this province.