The provincial government media office in a statement said at least 4 militants were killed during an operation by the Afghan forces in Pacher Agam district.
In the meantime, the Ministry of Defense (MoD), said at least 5 militants were killed during an airstrike in the same district.
He said a compound belonging to the loyalists of the terror group was targeted in the airstrike which destroyed in the raid.
The loyalists of the terror group have not commented regarding the report so far.
This comes as the local officials said Saturday at least 54 loyalists of the terror group were killed during a large scale operation launched in this province.
Nangarhar is among the relatively volatile provinces in eastern Afghanistan where both the Taliban insurgents and militants loyal to ISIS terrorist group are actively operating.
Both the Afghan forces and the US forces in Afghanistan are conducting regular raids against the Taliban insurgents and ISIS loyalist in the districts where they are conducting insurgency activities.
The US forces increased airstrikes against the Taliban insurgents and ISIS loyalists earlier this year after the Obama administration granted a broader role to the American forces.