The 201st Silab Corps in the East said the militants were killed in the past 24 hours in the vicinity of the restive Achin district.
The Silab Corps officials said the operations were conducted with the help of the air support in Tangi Mamand and Wach Zhwara areas.
The anti-government armed militant groups including the ISIS insurgents have not commented regarding the report so far.
The Silab Corps officials are saying that the Hamza operations are underway in the restive parts of Nangarhar province in a bid to eliminate the ISIS militants and insurgents belonging to the other terrorist groups.
The local officials said last week that a key Taliban local leader was arrested during an operation of the Afghan police forces in Chaparhar district.
The officials further added that the detained individual has been identified as Bismillah also famous as Ayoubi who was in charge of a group of at least twenty Taliban fighters and was actively involved in major terrorist related activities in Chaparhar and other parts of the province.
Bismillah was operating under the leadership of the Taliban group leader Ghazi Mansoor, the police commandment said, adding that he has confessed to his crimes and regrets for the killing the civilians and having role in other destructive activities.