The provincial police media office in Nangarhar said the drone strikes were carried out in Nazian and Achin district.
At least 6 of the militants were killed in Pekhi Kali area of Achin district and at least 3 others were wounded.
The remaining two ISIS loyalists were killed during another drone strike in Nazian district targeting the militants of the terror group in Milwa Kand area.
The local residents did not suffer any casualties in the airstrikes, the provincial police said.
The loyalists of the terror group have not commented regarding the report so far.
The latest airstrike by US forces comes as the Afghan Special Forces are busy in conducting a major operation against the loyalists of the terror group in Kot district.
The Ministry of Defense has said at least 300 ISIS loyalists have been killed so far and dozens of others were wounded.
The increased raids against the loyalists of the terror group come as there are concerns that the militants of the group are attempting to expand foothold in the country.
The top US general in Afghanistan in his latest remarks has said the loyalists of the terror group has direct links with the main group in Syria and Iraq.