MoD further added that the airstrike was carried out in Garamser district, leaving 7 Taliban commanders dead and 7 fighters of the group wounded.
According to MoD, Mullah Mujahid, Mullah Agha Mohammad also famous as Mullah Mashar, the former shadow district chief of the group, Mawlavi Mustafa and Mawlavi Hedayat were among those killed.
The Taliban militants group has not commented regarding the report so far.
Helmand is among the volatile provinces in southern Afghanistan where the Taliban insurgents are actively operating in its various districts and often carry out insurgency activities.
A huge weapons cache belonging to the Taliban group was discovered and destroyed in this province last month as the group was looking to use the weapons for executing attacks against the Afghan forces.
The cache included 10 rocket launchers, 400 rifle grenades, 12 hand grenades, 54 BM-16 rockets, 200 PK machine gun bullets, 5 motorcycles, one radio handset and some amount of explosives.
Officials in the 215th Maiwand Corps of the Afghan National Army (ANA) earlier said a factory producing Improvised Explosive Device (IED) for the Taliban militants was destroyed during an operation of the Afghan National Defense and Security Forces (ANDSF) in this province.