The US soldiers were reportedly partnering with the Afghan special forces during an operation in Nangarhar.
The top US commander in Afghanistan General John Nicholson has confirmed that five US soldiers were wounded in the last few days.
Without providing further information regarding the exact time of the incident, Gen. Nicholson told Reuters “None of these are life-threatening injuries.”
Gen. Nicholson further added that two of the injured service members have returned to duty, while three others were evacuated but are “in good spirits” and are expected to make a full recovery.
He said “We will continue to stay after Daesh until they are defeated here in Afghanistan.”
This comes as the Afghan commandos launched a major operation against the loyalists of the terror group in Nangarhar on Friday and cleared the restive Kot district from the presence of ISIS militants.
The operations were launched amid concerns that the terror group is attempting to expand insurgency activities in the country.
The group claimed responsibility behind a deadly bombing in Kabul that left at least 80 people dead and over 200 others wounded.