According to the security authorities, the airstrikes were conducted in different parts of the province, including Nazian and Haska Mina districts.
The officials further added that the loyalists of the terror group were targeted in the airstrikes on Saturday night.
At least 31 of the militants were killed in Haroon Baba area of Haska Mina district, the officials, said adding that 3 others were killed in a separate airstrike in Nazian district.
This comes as at least 9 loyalists of the terror group were killed in a similar airstrike in Achin district on Friday.
Nangarhar is among the relatively volatile provinces in eastern Afghanistan where both the Taliban insurgents and militants loyal to ISIS terrorist group are actively operating.
Both the Afghan forces and the US forces in Afghanistan are conducting regular raids against the Taliban insurgents and ISIS loyalist in the districts where they are conducting insurgency activities.
The US forces increased airstrikes against the Taliban insurgents and ISIS loyalists earlier this year after the Obama administration granted a broader role to the American forces.