The Ministry of Defense (MoD) said at least 29 militants were also wounded during the operations which were conducted in Faryab, Herat, Baghlan, Helmand, and Maidan Wardak provinces.
A statement by MoD said at least 18 of the militants were killed and 21 others were wounded in Garzewan district of Faryab, while 7 others were killed and 3 more were wounded in Shindand district of Herat.
The statement further added that 3 militants were killed and 5 others were wounded during a separate operation in Dand-e-Shahabuddin district of Baghlan.
At least 4 militants were killed during an operation in Greshk district of southern Helmand province, MoD said, adding that another militant was killed in Nerkh district of Maidan Wardak.
According to MoD, a soldier of the Afghan National Army (ANA) forces also lost his life during the operations.
The anti-government armed militant groups have not commented regarding the reports so far.
The Afghan National Security Forces (ANSF) have stepped up crackdown on anti-government armed militant groups to suppress their insurgency activities amid deteriorating security situation.
This comes as the Taliban-led insurgency has been rampant since the group announced their summer offensive earlier this month and vowed to carry out more attacks across the country.