Local officials said the airstrike was carried out by the foreign forces in Achin district where the loyalists of the terror group are actively operating.
The provincial government media office in a statement said at least three commanders of the terror group were among those killed.
The statement further added that some weapons and ammunition belonging to the loyalists of the terror group were also destroyed.
The anti-government armed militant groups have not commented regarding the report so far.
This comes as at least 12 loyalists of the terror group were killed in a similar raid in Kot district of Nangarhar last week.
The US forces stepped up airstrikes against the ISIS loyalists earlier this year after they were granted more authorities by President Barack Obama.
The increased raids against ISIS loyalists followed amid concerns that they are attempting to expand foothold in the country besides attempting to consolidate operations with the terror group in Iraq and Syria.