A statement issued by the ministry states that the operations were carried out in Heart, Nimroz, Maidan Wardak, Paktiya, Takhar, Kunduz, Faryab, Sar-e-Pul, Balkh, Kandahar, Zabul and Oruzgan provinces in past 24 hours.
The statement adds that the operations were jointly conducted by Afghan National Police, Afghan National Army and personnel from the National Directorate of Security (NDS) leaving 22 insurgents killed, nine wounded and three others arrested.
This comes as 25 other rebels were killed in a drone strike in eastern Nangarhar province, also yesterday.
Starting January this year, it has been one of the deadliest periods for militants in Afghanistan.
According to security officials, the militant groups lost more than 2000 fighters during this period and some important commanders.