The 201st Silab Corps of the Afghan Military in the East in a statement said the airstrikes were carried out on Sunday in Khogyani district.
The statement further added that the coalition forces carried out airstrikes using unmanned aerial vehicles, targeting ISIS militants in Sikanar area of Wazir Tangi.
According to 201st Silab, at least 21 militants affiliated with the terror group were killed in the airstrike.
The anti-government armed militant groups including ISIS loyalists have not commented regarding the airstrike so far.
Nangarhar is among the relatively calm provinces in East of Afghanistan but the Taliban militants and ISIS loyalists have been attempting to expand their foothold and activities in this province.
However, the Afghan and U.S. often conducted counter-terrorism operations and airstrikes to suppress the anti-government armed militants.