The NATO-led Resolute Support mission said the two soldiers sustained minor injuries after their vehicle struck an Improvised Explosive Device (IED).
“2 US soldiers suffered minor injuries when an IED struck their vehicle while conducting a force protection patrol near Jalalabad Nangarhar,” the alliance said in a Twitter message.
This comes as at least five US soldiers have sustained injuries during an operation in eastern Nangarhar province of Afghanistan late last month.
The US soldiers were reportedly partnering with the Afghan special forces during an operation in Nangarhar.
The Afghan commandos launched a major operation against the loyalists of the terror group in Nangarhar more than two weeks ago and cleared the restive Kot district from the presence of ISIS militants.
The operations were launched amid concerns that the terror group is attempting to expand insurgency activities in the country.
The group claimed responsibility behind a deadly bombing in Kabul that left at least 80 people dead and over 200 others wounded.