The Ministry of Interior (MoI) said the two top Taliban commanders were killed in Deh Yak and Gilan districts of Ghazni on Friday.
A statement by MoI said one of the commanders was identified as Khalid who was killed along with his 3 companions on Friday night.
The statement further added that 3 militants were also wounded in the ambush while the commander was killed in Gilan district.
According to MoI, the second Taliban commander was involved in major terrorist related activities and their elimination will have a positive impact on security situation of the country.
The Afghan police forces have also seized some weapons and ammunition after killing the Taliban commanders, MoI added.
The Taliban militants group has not commented regarding the report so far.
Ghazni is among the volatile provinces in southeastern Afghanistan where anti-government armed militant groups including the Taliban insurgents are actively operating and frequently carry out insurgency activities.